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The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.
Thus, a significant proportion of the enteric pathology reflects the widespread sympathetic degeneration seen in other systems [30], [31].
We have therefore conducted the present study in a larger set of 30 PD patients to allow in depth analysis of enteric pathology throughout the colonic SMP, and to correlate the extent of pathology with motor symptoms and constipation.
SHIP-deficient mice developed segmental, transmural pyo-granulomatous ilietis that recapitulated classical features of Crohn's disease enteric pathology.
The absence of enteric pathology in SHIP−/− hosts reconstituted with WT BM indicates that SHIP-deficiency does not cause an IEC functional barrier defect leading to ileitis.
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Within this miscellaneous group of enteric pathologies, some diseases appear to possess peculiar features, such as the epizootic rabbit enteropathy, enterotoxemia caused by Clostridium spiriforme and C. perfrigens (29 ), C. difficile (30 ) infection, Tyzzer disease (caused by C. piliformis), mucoid enteropathy, Escherichia coli enteritis, and coccidiosis (31 ).
A key hypothesis of the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial is that a subclinical intestinal pathology, termed environmental enteric dysfunction (EED), underlies child stunting [ 1].
Additionally, the clinical significance of these extra-enteric pathologies has never been evaluated.
The German pathologist Heiko Braak suggested that the appearance of Lewy pathology in enteric neurons develop early in the course of disease, prior to the involvement of the central nervous system [ 11].
Tocchi et al. reported a rate of 5.5%%, where 55 out of 1000 cases developed cholangiocarcinoma after biliary enteric anastomoses for benign pathologies [6].
This procedure partially prevents the spread of pathology from the enteric nervous system to the CNS resulting in a decreased dopaminergic cell death.
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