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Due to the official negative attitude to methadone maintenance in Sweden before 2005, a maximum of 800 patients were allowed to enter the maintenance programs [ 8].
Patients who failed to respond to the 1st-, 2nd-, and 3rd-line treatments in the acute phase enter the maintenance phase as non-responders and on triple therapy (AA + VPA + Li).
Patients with adequate pain relief and no intolerable AEs (responders) were assumed to enter the maintenance treatment phase, where they remained unless they discontinued therapy or ceased to have sufficient pain relief.
Patients who fail to achieve their target weight loss can choose to repeat phase 2 once more and then enter the maintenance programme or if they fail to lose 5 kg and have a BMI >40 kg/m, or BMI>35 kg/m with comorbidities, can opt for bariatric surgery.
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There were 195 patients enrolled in each group; 108 high-hemoglobin and 133 low-hemoglobin patients entered the maintenance phase.
I ran six illustrative simulations (Ia to IIIb, see table 2), to demonstrate the dynamics of the consecutive application of the algorithm until the system enters the maintenance state.
The definitions of the functions, vectors, matrices and equations (see Notation in Appendix S1) used for the simulations are given with the following additional assumptions: For t0 = 0 the initial state of the system is the reliability state R. The algorithm is applied until the system enters the maintenance state.
Following recovery, treatment enters the maintenance stage.
Ten subjects entered the maintenance phase of this study.
Nonprogressive patients entered the maintenance phase with B 10 mg/kg plus FTM 75 mg/m every 3 weeks.
All patients who entered the maintenance phase met the DSM-IV criteria for PD (n = 85) or PDA (n = 58).
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