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Recruitment of subjects is straightforward; no one's walking off the street to enter a trial for stroke patients.
These doctors also may discourage patients from going elsewhere to enter a trial: if a patient leaves, the doctor loses business.
To enroll in the Obama administration's $75 billion "Making Home Affordable" program, borrowers enter a trial period in which they make at least three payments.
Thirty-six patients (5.4%) were lost to follow-up or it was unclear why they did not enter a trial.
Factors that influence the decision to decline the invitation to enter a trial are poorly known [ 29].
For example, the values of trust and honesty may be more significant to participants who are willing to enter a trial based on their physicians' recommendations.
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He added that patients in trials often fared better than those not in trials, and he described entering a trial as "actually a very smart thing for a patient to do".
And if there is no standard treatment for an illness being studied, patients entering a trial may be assigned randomly to a control group that is being given placebos, a prospect that many find discouraging.
In clinical trials, a covariate-adjusted response-adaptive (CARA) design allows a subject newly entering a trial a better chance of being allocated to a superior treatment regimen based on cumulative information from previous subjects, and adjusts the allocation according to individual covariate information.
Randomization or inclusion of a placebo arm can deter eligible patients from entering a trial [ 13].
Patients should be aware that there is always an added value in entering a trial.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com