Working in human dermal fibroblasts, Koch et al. (36) found evidence that aging entails regulated developmental mechanisms at the level of DNA methylation.
In the present experiment regional Fos expression was compared between rats trained under an immediate timing schedule, the free-operant psychophysical procedure (FOPP), which entails temporally regulated switching between two operanda, and a yoked variable-interval (VI) schedule matched to the timing task for food deprivation level, reinforcement rate and overall response rate.
Ubiquitylation entails a highly regulated enzymatic cascade involving ubiquitin activating (E1), ubiquitin conjugating (E2), and ubiquitin ligating (E3) enzymes [ 6].
Foucault once wrote that, "knowledge, once used to regulate the conduct of others, entails constraint, regulation and the disciplining of practice" [ 12].
All knowledge, once applied in the real world, has effects, and in that sense at least, 'becomes true.' Knowledge, once used to regulate the conduct of others, entails constraint, regulation and the disciplining of practice.
As the use of pharmacological inhibitors entails the risk of regulating cascades other than the targeted, we used siRNA to down-regulate PKC-α expression in OPCs plated on myelin (Fig. 5).
In the case of the budding yeast, Saccharomyces cerevisiae, cell division entails a complex and highly regulated series of morphological and genetic changes (Fig. 1).
Investigating the governing dynamics that regulate such systems entails experimentation of the trial-and-error flavour, but the, sometimes, colossal gaps between system outputs under slightly varying initial conditions have done little to decrypt the black-box-like modus-operandi of such systems.
Wound repair, collagen deposition, and fibrosis are tightly regulated processes entailing multiple potential pathways with compensatory mechanisms for collagen reabsorption that is primarily performed by the matrix metalloproteinases and modulated by TIMP [58 60].
As exemplified above, the principle of miRNA pharmacogenomics entails that increased miRNA expression down-regulates genes encoding proteins that promote drug efficacy.
