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Many of the sceptics demand a referendum because they say the treaty entails a significant transfer of power from the UK to the EU.
Professor Martin Evison, director of Northumbria University Centre for Forensic Science, said: "It [the market] is working, however it entails a significant degree of risk that one of the major providers might decide that it's not worth their while to stay in the game".
Therefore, our encoding of the conformational space entails a significant performance gain on the EGFr data set.
The application of 3D methods on multiple conformer data sets normally reduces this weakness, but entails a significant computational overhead.
The results clearly indicate that the planar K-function analysis is problematic since it entails a significant chance of over-detecting clustered patterns.
Handling the enormous quantities of sludge entails a significant proportion of the overall operating costs of water-treatment works, and precisely for this reason, appropriate reuse strategies that are sustainable from an environmental and economic point of view are needed.
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If that drop is permanent, it would alone entail a significant decline in the level of potential output.
"On a more positive note, the very sharp falls in industrial output in Sweden have entailed a significant drawdown of inventories," said Varun Bhabha, an analyst at Barclays Capital.
It was indeed "tabloid gold" designed to appeal to prurience, and it did entail a significant intrusion on the claimant's private life.
As a result, that C.E.O. is likely to embrace projects that promise big rewards, even if they also entail a significant chance of failure.
To back down now would entail a significant loss of credibility for the international institutions and governments pressing Mr. Gbagbo, analysts contend.
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