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Batch effects and differences in sample preparation can have substantial ramifications on the outcomes.
Both moves typically entail substantial new R&D and marketing capabilities and are fraught with risks.
The analysts added that the potential deal would likely entail "substantial" cost savings over three years.
At the same time that Clarke relinquished his selectorial powers, Darren Lehmann was appointed coach, a move that had substantial ramifications for the wisdom of Clarke's decision.
The Court's ultimate decision in this case will have substantial ramifications for seamen, who face substantial risk and hardship in their daily lives and rely on the "ancient duty" of shipowners to provide them with maintenance and cure.
Providers can offer such a product, but going beyond the standard plain-vanilla product is likely to entail substantial risks.
Due to low pH soils which are common in this region, N removal by denitrification may entail substantial N2O emissions.
A recent document by the ECB said restoring a member state's old currency would "inevitably involve considerable risks and difficulties and entail substantial legal complications".
Also, he knew that a replacement engine would entail substantial redesign work to the aircraft, and it'd probably send the price over the $1 million mark.
Though few concepts require all-or-nothing investments, as the launch of Federal Express did, many do entail substantial up-front expenditures.
And moving back into a world of ash and rubble would entail substantial health risks, especially for someone with breathing issues, as Mr. Cayer well knows.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com