Neuronal functions of the Importin-α family have been reported recently in several systems [9], [10], [11], [13], and like the importin-α2 phenotypes described here, can entail regulation of the synapse.
FGF signalling controls normal endothelial function that likely involves a certain level of energy production, which in turn may entail regulation of basal levels of PFKFB3 expression.
The fact is that good climate policy will entail regulations that are anathema to some.
As there is no cure for T1DM, management entails regulation of blood glucose levels with insulin replacement therapy and dietary modification.
Foucault once wrote that, "knowledge, once used to regulate the conduct of others, entails constraint, regulation and the disciplining of practice" [ 12].
All knowledge, once applied in the real world, has effects, and in that sense at least, 'becomes true.' Knowledge, once used to regulate the conduct of others, entails constraint, regulation and the disciplining of practice.
Years ago, the government piously promised that federal aid to education would entail no regulations or intrusions.
According to this and the novel connection between AnxA1 and HDACIs found in our results, we can hypothesise that - in line with anti-cancer activities [43] - the anti-inflammatory mechanism of action of HDACIs (still a matter of debate) could entail up-regulation of one of the effectors of endogenous anti-inflammatory processes, the protein AnxA1.
The former frequently entails a regulation of gene expression via the exclusion or inclusion of regulatory elements such as miRNA- and RBPs-binding sites, whereas the latter contributes to the diversity of the proteome.
Clinton's economic vision entailed "onerous regulations", which would put small companies "totally out of business, and you won't be able to start – you could never, ever start – a small business under the tremendous regulatory burden that you have today in our country".
Furthermore, we analyzed if higher methylation of C1R entails down-regulation of the corresponding gene, but there was only a moderate association from RNA-seq data (R = 0.35, Fig. 2c).
