Simulation-optimization method entails a large number of model simulations, which is computationally intensive or even prohibitive if the model simulation is extremely time-consuming.
Bayesian inference using Markov Chain Monte Carlo (MCMC) provides an explicit framework for stochastic calibration of hydrogeologic models accounting for uncertainties; however, the MCMC sampling entails a large number of model calls, and could easily become computationally unwieldy if the high-fidelity hydrogeologic model simulation is time consuming.
In many countries telephone advice nursing is the patient's first contact with healthcare, and the service entails a large number of patient contacts.
The suggestion to compare sex differences entails a large number of possible permutations and combinations (e.g. differences in calling behaviour and neuronal responses in relation to sex, estrous state, in and out of touch etc).. Inclusion of all this data is outside the scope of this manuscript and we would like to present this data in a separate manuscript.
Hence, the distribution of secondary plastids among the chromalveolates might have entailed a larger number of symbioses than the chromalveolate hypothesis suggests (Becker et al. 2008; Sanchez-Puerta and Delwiche 2008; Moustafa et al. 2009; Nozaki et al. 2009).
However, the rationale for performing an OGTT in all patients with FPG < 110 mg/dL (6.1 mmol/L) was not substantiated and such practice may also entail testing a large number of patients, which may not be feasible.
The proportion of borrowers facing financial ruin because of an unwise or fraudulent ARM may be small, but it is large enough to exert a downward pull on the housing market generally - hence it affects all of us - and even absent any self-interest, it entails that a large number of people are really suffering.
For instance, students were expected to read Cicero's orations before they went on to logic, which entailed memorizing a large number of rules and mnemonic aids such as the pons asinorum, which helped them to find the correct middle terms for various types of syllogism.
The outcome of each run of the simulator, entailing the generation of a large number of pseudo-casual numbers, is taken to simulate the results of one mouse, thus reproducing experimental variability between individual mice.
Our approach begins by using a Monte Carlo multiple minimization (MCMM) approach, which basically entails performing the minimization for a large number of widely dispersed initial values.
