Exact(2)
Apoptosis induced by the engagement of FasL with Fas receptor on the surface of lymphocytes is an important immune homeostatic mechanism that ensures tolerance to self-antigens under normal physiologic conditions.
Although the exact mechanisms are not all unravelled, this ensures tolerance to the resident microbiota in adults.
Similar(58)
Haematopoietic cells most efficiently delete thymocytes with high affinity for self-MHC peptide complexeself-MHC peptide tolerancomplexes donor and hosthus
Mouse immune systems interact to ensure tolerance to nonpathogenic bacteria in the gut.
These data strongly suggest skinstage parasites capitalize on host responses to isolated, uninfected Anopheline bites, (which are normally immunosuppressive [257]), efficiently misdirecting systemic responses to ensure tolerance to subsequently developing parasites.
Participants subsequently underwent a 6-day run-in period in which participants ate meals from each study diet for 2 days to ensure tolerance to study foods.
Each aliquot was withdrawn over approximately 10 minutes, during which time the patient's vital signs were continuously monitored to ensure tolerance to this controlled hemorrhage.
To prevent autoimmunity, the differentiation of lymphocytes is accompanied by selective mechanisms that ensure tolerance to self-components through the destruction or the inactivation of autoreactive clones [ 1]. (3) While the bone marrow produces fresh immune cells, the thymus selects those cells that are immunocompetent and are allowed to enter the body.
Since the expression of CD45RO indicates previous antigen contact, we speculate that cord blood CD45RO+ NKT cells are functionally mature and migrate to lymphatic tissue to ensure tolerance during in utero exposure to antigens.
A possible mechanism to ensure tolerance of the anaphase B spindle against chromosome segregation errors would be to externally reinforce the spindle with an elastic material (Mitchison et al., 2005; Brangwynne et al., 2006).
Allostasis in the NF-κB system found in the present study may ensure tolerance and/or compensatory response to excessive stimulation in chronic alcoholics.
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