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This is highly desirable as it supersedes the laborious task of antigen purification and ensures presentation of target proteins in their native conformation.
With our mRNA-based DC vaccine, the patient's HLA type is not known and the full-length TAA encoding mRNA ensures presentation of the full antigenic spectrum of epitopes, which impedes the use of direct tetramer staining.
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Specifically, trial order was randomized for each block and adjusted to ensure presentation of no more than 5 trials of a particular type in a row (e.g. scenes, commonness judgment), in order to avoid confusion for the participant potentially caused by a long sequence of similar trials.
coordinating suppliers, handling client queries and troubleshooting on the day of the event to ensure that all runs smoothly; speaker/stage management on the day, ensuring presentations and panel discussions run according to schedule; post-event evaluation and accounts.
In mycobacterial infection, CD1 ensures the presentation of the glycolipids unique to the mycobacterial cell wall to activate CD1-restricted T cells and is thereby involved in shaping the immune response (Porcelli et al., 1998; Sieling et al., 1999; Barral & Brenner, 2007;).
They carry out pre-tests to ensure the presentation of their results to the release manager.
Researchers provide each site with a PowerPoint slide template to complete to ensure systematic presentation and data collection.
The UPSK seems to act as an important, though nonspecific, spacer element ensuring proper presentation of a functional TLS.
"The aim of the STROBE guideline is to ensure clear presentation of what was planned, done and found in observational studies" [23].
They manage studies, ensure timely presentation and publication of results, serve as clinical and information resource for physicians and other health care personnel, organize and present educational programs, and provide clinical training for field sales staff.
Antigens that are rather stable to endolysosomal proteolysis can persistently provide peptides for binding to MHC molecules, thus ensuring efficient presentation to T cells and thus, high immunogenicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com