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Our main objective was to ensure that the methodology for each review could be clearly described (and replicated) and that the methodological choices were well aligned with the research questions.
Key strengths of this study include the efforts undertaken to ensure that the methodology was culturally appropriate, the relatively large and representative sample, and the use of well-validated assessment tools.
Thus future proteomic studies on mucus, from whatever tissue, should ensure that the methodology does not exclude these important glycoproteins.
This is done to ensure that the methodology chosen conforms to the problem at hand in the most optimal and efficient manner.
An online approach was used to ensure that the methodology was globally consistent while avoiding the need to rely on treatment centres for recruitment and taking into account the difficulty in implementing a telephone survey in countries such as China and Brazil.
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To ensure that the methodologies are scalable for complex structures with many sensors, a clustering algorithm groups sensors that have strong correlations between their measurements.
To this end, it will be essential to ensure that the methodologies are clearly and completely explained.
Formal codes of practice are now the norm, with the goal of ensuring that the methodology is rigorous; that potential harm to participants is minimised; that people know exactly what they are signing up to; and that the potential benefits of study outcomes outweigh possible risks of safety or confidentiality.
This process ensured that the methodologies are complementary and helpful in shedding light on the processes of policy-making in a comprehensive way and from different perspectives.
While there are inherent difficulties in collecting high quality data in conflict settings, there is an obligation to ensure that the research methodology being applied is of the highest standard, whether this is via a simple qualitative survey (gathering testimonies of refugees fleeing conflict) or a cohort study (most commonly the retrospective analysis of routinely collected data).
Modifying the Delphi approach is however considered appropriate to ensure that that methodology is appropriate for the study aims rather than shaping the study aims to fit the methodology.
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