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The empowered communities report promotes a subsidiarity funding model, to ensure targeted program delivery and avoid the bleeding of funds through administration costs.
In particular, there is great interest in the development of nanoparticle-based vectors that decrease the toxicity of free drugs and ensure targeted delivery directly to tumor cells [30 33].
Genome editing (GE) tools ensure targeted mutagenesis and sequence-specific modification in plants using a wide resource of customized endonucleases; namely, zinc-finger nucleases (ZFNs), and transcription activator-like effector nucleases (TALENs), and the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) system.
This would ensure targeted drug deliveries to mycobacterium reservoirs, reduction in the duration of therapeutic treatment, and a decline in systemic toxicities.
Transcription factors, regulating the expression inventory of a cell, interact with its respective DNA subjugated by a specific recognition pattern, which if well exploited may ensure targeted genome engineering.
As in other south Asian countries [ 2, 8], the pharmaceutical companies in Bangladesh have developed a comprehensive, evidence-based system (through 'history' taking of physicians and monitoring of prescriptions) in order to guarantee that enough prescriptions are generated to ensure targeted market share.
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The tobacco etch virus NIa protease (TEVp) is a good candidate for this strategy as the canonical substrate recognition sequence (ENLYFQ/G) is sufficiently unique to ensure targeting specificity [5].
Somewhat counter-intuitively, the non-directional, but rapid, motion of proteins within the cell nucleus provides a means to ensure targeting of proteins to specific genome locations (Misteli 2001).
Magnetic hyperthermia is a non-invasive technique which is better than the other hyperthermia techniques as it ensures targeted heating of the tumor tissue [3, 4].
In this short note, we show how to use a highly accurate finite-difference scheme to compute second derivatives in the Navier Stokes equations while ensuring targeted numerical dissipation.
For example, the 3D structure of a lymph node ensures targeted positioning of interacting cells, facilitates T cell migration towards DC, supports motility upon cell-cell interaction and provides traction for amoeboid T cell crawling within the DC compartment.
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