The kinase activity of mitochondrial DMPK protects cells from oxidative stress and from the ensuing opening of the mitochondrial permeability transition pore (PTP), which would otherwise irreversibly commit cells to death.
Activation of cell surface receptors coupled to Ca2+ mobilization from intracellular stores and ensuing opening of calcium-release activated channels (CRAC) leads to the activation of Ca2+-dependent enzymes, in particular, the calcineurin (Cn) protein phosphatase.
The ensuing excess opening of cGMP-gated cation channels causes intracellular calcium to rise to toxic levels.
A direct comparison of quenching slopes, however, underestimates the difference in activation because quenching rates after acute exposure to hypotonicity (but not with drug preincubation) also reflect the time course of cell swelling and ensuing VRAC opening (Appendix Fig S2A and E).
We have recently reported that inhibition of SDH by TRAP1 promotes tumor growth by protecting neoplastic cells from oxidative insults and from the ensuing lethal opening of the PTP, and this anti-oxidant activity of TRAP1 becomes particularly important in conditions of nutrient paucity that mimic those encountered in the tumor mass during the process of unrestrained malignant growth [157].
Grabbing all the theme park headlines this year (not least because of its late opening, and ensuing technical problems), Alton Towers' new ride, The Smiler, fulfils its dubious promise to "marmalise" riders through its world-record 14 loops.
The ensuing discussion is my opening for bringing up examples from advertising, commercials, and, of course, politics, especially as they relate to science.
The conversation with the gangsters that ensued is the opening of your book.
After a graceful rendition of the Impromptu in B-flat (D. 935, No. 3), he offered a poetic interpretation of the G-flat (D. 899, No. 3), building in an arc from the introspective opening to turbulent ensuing sections.
In the club's ensuing match, Ribéry scored the opening goal in the team's 2 1 victory over Schalke.
The message that child rights priorities trump party politics was consistently reiterated in the opening remarks, presentations, and ensuing discussions.
