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When adherence to the prescribed drug dosage is known, true dose response can be validly estimated, while non-compliance with the nominal prescribed dosage causes unintended variability in actual drug exposure and ensuing difficulty in determining dose response.
Much has been said recently about the increasingly rigid orthodoxy that we are seeing in our national dialogue -- and the ensuing difficulty in resolving a host of issues critical to our country's future.
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The war in Iraq and the ensuing difficulties there represented a turning point.
Fortunately, the Samoans have often proved ingenious at overcoming the ensuing difficulties.
The police will have to handle any ensuing difficulties with restraint.
As genomic technologies continue to advance, we look forward to their many positive contributions to the health of our populations while pursuing the answers to ensuing difficulties.
With polychoric, two factors are identified (scar issues and ensuing difficulties with item 1 loading weakly on F1); the first factor explains 66% of the variance and the first two factors explain 80%, suggesting two factors.
But "we then see a marked difference in year seven, where favoured books are no longer above chronological age, but six months below it and in ensuing years the difficulty of books plateaus or declines," he added.
Whilst many people have low levels of mutated mitochondria in their cells, with little or no difficulties ensuing, those with higher levels can have serious health issues.
Given the likely difficulties ensuing from a monomer production imbalance in a polymer/dimer polymerisation equation it is understandable that cells have developed transcriptional and post-transcriptional controls to regulate equivalent amounts of α and β tubulin [ 56].
Confronted with multimorbidity and its ensuing problems GPs experience difficulties in identifying ADEs, and take the patient's judgement in this matter seriously.
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CEO of Professional Science Editing for Scientists @ prosciediting.com