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Follow-up of study units from enrolment to study completion minimizes the risk of attrition bias (systematic differences between groups in withdrawals from a study/loss of samples).
Observation time was calculated from date of enrolment to study end date except where there was loss to follow up, diagnosis of TB, consent withdrawal or death.
§Nominated by patient at enrolment to study.
As for clinical failure, microbiological failure was variably assessed at 48 to 96 hours after enrolment to study or from start of the study drugs.
McManus had, as dependent variable, receipt of one or more offers to study medicine; Gallagher et al. investigated offers among applicants focused on admission to medicine; we used actual admission or enrolment to study medicine.
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Clinical failure was variably assessed between 48 to 96 hours after enrolment to the study or from starting to take the study drugs.
All patients gave written informed consent prior to study enrolment.
Patients gave their informed, written consent prior to study enrolment.
Infusions were always started prior to study enrolment.
No patients had taken statins prior to study enrolment.
Written owner consent was obtained prior to study enrolment.
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