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Considering that approximately 15% of enrolled subjects might withdraw or be unevaluable for immunogenicity; the target enrolment size was 600 subjects (150 subjects per vaccine group).
Schools were selected with probability proportional to school enrolment size.
The health facility sub-samples were chosen by systematic sampling proportional to clinic enrolment size.
A preliminary analysis examined group differences in weather conditions, missing observation data, and school enrolment size.
In the first stage, primary sampling units were schools which were selected with a probability proportional to their enrolment size.
21 22 Briefly, 85 secondary schools were randomly selected from all secondary schools (about 500) with a probability proportional to the school enrolment size.
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The study schools were a mix of types and enrolment sizes.
The minimum enrolment sample size will include 150 surgical patients, 200 patients receiving intensive medical therapy and 150 patients wait-listed to enter the clinic.
The relative efficiencyof statistical modelling of treatment contrasts was also affected by ICC, distribution of patient enrolment, centre size and the number of centres.
In engineering education, where the enrolment and class size is high, PBL is more practical although the implementation is difficult to monitor.
For any studies where insufficient detail is given to determine eligibility (eg, minimum age of enrolment or sample size), we will contact the corresponding author by email (without a reminder) to seek clarification.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com