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Additionally, some confounders, such as period of enrolment of different RCTs, cannot be adequately corrected, limiting the possibility of indirect comparisons for specific outcomes (e.g., radiographic progression) [ 70].
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Meta-analysis overcomes Simpson's paradox by accounting for the enrolment of patients in different studies.
The enrolment of patients with different types of antigenic stimuli has been implicated as a great disadvantage in the evaluation of clinical trials on sepsis [ 6].
One of the major advantages of our study was the enrolment of patients evincing different disease severity; patients with milder symptoms and signs as well as patients with septic shock who needed ICU treatment.
Treg cells dynamically change with the development of disease activity, and the enrolment of SSc patients with different disease activities might contribute to the discrepancy in the percentage of Treg cells among different studies.
The investigators have discussed a mandatory ICD programming; however, due to enrolment of patients in five different countries and with a wide variety of ICD indications, this has not been deemed possible.
Additional regression analyses (not shown) indicated that, in each of the three study sites, the probability of MHO enrolment among those in the top quintile was significantly higher than for everyone else, while there was no evidence that the probability of enrolment of the poorest quintile is different than that of the other four quintiles grouped together.
The time patients spent in ADHERE varied because of the rolling enrolment from CHARM, different timing of study site closure and movement of patients to commercial drug.
The manner in which enrolment and mobilization progressed is described below through the experiences of different actors.
What is different is that childcare enrolment of children under age five has increased massively from 2000 to the present in sheer numbers (from 686,000 children in 2000, 989,390 in 2005 to 1,348,729 children in 2011).
This study is part of the IMPACT project, in which enrolment of patients in trials is studied at different levels [ 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com