As each source of patients was mainly constituted by a specific target of MS disease stage, multiple sources of enrolment were necessary.
If Zambia were able to replicate these results, the expansion of doctor training enrolment, while still necessary, would not have to be as extreme.
However, after the first six months of enrolment, it became necessary to open enrolment to all private pediatric and family physician practices, regardless of practice volume, in order to achieve the goal of 120 enrolled practices.
Necessary enrolment increases can be held to a minimum if the rates of retention, graduation, and public sector entry increase to 100% by 2010, but will need to increase if these rates remain at 2008 levels.
The study complies with the Helsinki statement on research ethics and due to the non-interventional character of this study; approval by the medical ethical committee at time of enrolment was not necessary according to Dutch law.
To summarise in NPT terms, we can see how cognitive participation – the enrolment of the actors necessary to make the intervention work – took place in this case.
As a mid-range scenario, decreasing attrition by five percentage points for doctors could change the necessary training enrolment increase from thirteen times to ten times current levels.
As the outcome was observed over a 6-month period, it was necessary to suspend enrolment after the first 20 patients were enrolled to determine if the trial should be stopped or continued.
TIIS thus serves as one-stop shop for information necessary for monitoring enrolment, production and projection of the health workforce.
For clinical trial enrolment although exclusion criteria are necessary to minimise confounding, too strict inclusion may result in a sample not reflective of the population for whom the treatment is being sought.
