Sentence examples for enrolment dose from inspiring English sources

We have reviewed characteristics of three alternative design options from an early (Phase 2) drug development perspective; enriched enrolment, dose titration and adaptive dosing.

This approach, coupled with innovative clinical trial designs that promote patient enrolment to doses that are likely to be effective, and the use of clinical centres with proven expertise in early clinical trials, ensures that the need to select a safe starting dose and animal welfare issues are appropriately balanced.

If three of three patients or at least four of six patients experienced the DLT, enrolment at this dose level was ceased, the dose level was determined as the MTD, and the preceding dose level was designated as the RD for the phase II study.

Thus, enrolment continued to dose level 2. Four patients were enrolled into the dose level 2 cohort (capecitabine 600 mg/m), as one patient was erroneously taking half of the prescribed dose of capecitabine (300 mg/m) and was replaced for DLT evaluation.

At the time of enrolment, investigators selected dose based on patient's then-current oral MTX regimen (10, 15, 20 or 25 mg weekly).

The univariable and multivariable risk factors identified in those studies are shown in Supplemental Tables 1 and 2. Clinical covariates in the current study were included based on the previous analyses as follows: (lumefantrine or amodiaquine dose, enrolment parasitemia, age category, and ASAQ fixed or co-blistered versus loose formulation (Table 1).

Enrolment in the higher dose cohorts began only if the initial 50-mg QD dose was well tolerated (four or more patients with no DLTs).

Accordingly, enrolment was halted and dose level 0 was determined to be the MTD.

Neither the age of enrolment nor the GOS dose seemed to affect the differences found.

Factors influencing the selection of the IVIG dose before enrolment were not standardized.

If two or more patients presented with DLT at a dose level, enrolment of patients to that dose level was discontinued and the immediately preceding dose level was considered the MTD.