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Following enrolment, cases were excluded if the scheduled colonoscopy was cancelled or if insufficient blood was available.
In the event of complications arising after study enrolment, cases will be handled individually (see Intervention deviation section).
To confirm appropriateness of enrolment, cases were subsequently re-evaluated by independent reviewers based on clinical charts and written requests for urgent CT originally filled out by the caring physician.
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The difficulty in enrolling cases and controls may reflect the type of enrolment procedure used.
Table 1 shows the distribution of selected characteristics at enrolment among cases and non-cases, and according to anatomical distribution of tumors.
INCANT is firmly underway, with steady enrolment of cases.
Fig. 1 provides the enrolment of cases under the SARI and GERMS programs, including co-enrolment.
The process for the recruitment and enrolment of cases and controls is summarised in Fig. 1.
Patients diagnosed with HCC within the first 6 months of enrolment (prevalent cases) were excluded.
Blood collection will be requested at time of enrolment for cases, controls and additional members of control households.
Enrolment of cases occurred between 1 September 2001 and 31 October 2004 in Maine and Vermont and between 1 January 2002 and 31 July 2004 in New Hampshire.
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