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In total, 128 children < 19 years of age at the time of enrollment participated in the community-based health screenings.
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At the one-year anniversary from enrollment, participating women could be further randomized into a CaD supplementation component.
MLPK was responsible for patient enrollment and participated in the design of the study.
LSG and AGC were responsible for patient enrollment and participated in the genetic analysis.
As shown in Table 1, an estimated 80.3% of the population resident in the water districts during the enrollment period participated in the Project, with a slightly higher proportion of women compared with men participating.
The cohort included 652,792 Norwegians (49% men), most of whom were aged 19 to 67 years at enrollment, who participated in four different Norwegian health surveys initiated by the National Health Screening Service (now included in the Norwegian Institute of Public Health).
Three months post enrollment, practitioners participated in a one-day, in-person CAMR training workshop with a pre-test assessment immediately before the training and a post-test immediately afterwards.
Patients who could not safely discontinue use of all IOP-lowering medications for a minimum period of 3 ± 1 to 28 ± 1 days before enrollment, had participated in any other investigational study ≤30 days before screening, or had used any systemic (oral), injectable, or topical steroids were also excluded.
Wide variability in patient enrollment among participating sites is a common phenomenon in multicenter trials.
All these characteristics were previously reported as factors related to the influence of monetary incentives in the enrollment to participate in clinical trials.[25] [29], but surprisingly in our results that factor is the least important.
This outcome is dependent on broad enrollment from participating centers.
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