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The major risk factor for CIN is pre-existing renal insufficiency which was not an enrollment criterion in this study.
Only 25% of CLEAR I RA participants had erosions at baseline, given the enrollment criterion of disease onset <2 years.
The continuous enrollment criterion was imposed to ensure that the selected patients had adequate and uniform in length preindex and postindex follow-up data.
The primary enrollment criterion for our original study was thus colon resection; however, only about half of our patients had surgery for cancer.
The principal enrollment criterion for chronic cough patients was the intention of their doctor to initiate a therapeutic trial of proton pump inhibition as an effort to make a diagnosis of possible acid reflux cough.
This time could be as little as one month for an already-developed assay (e.g., a single prevalidated SNP TaqMan assay) to more than six months for a complex assay (e.g., multianalyte flow cytometry or microarray-based RNA expression signature) or for an assay that has not been deployed previously as a patient enrollment criterion.
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The tracking database checked for internal consistency (e.g., residents who met enrollment criteria were enrolled).
To mitigate this, we enrolled all consecutive patients meeting our enrollment criteria.
It is possible that few patients seeking health care very early in their illness may not meet study enrollment criteria and therefore not been enrolled.
We attempted to mitigate this by enrolling consecutive patients fitting the pre-determined enrollment criteria.
We attempted to mitigate this by enrolling consecutive patients meeting the pre-specified enrollment criteria.
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