The next highest enrolling region was Western Europe/Israel, with 981 participants (21%) enrolled.
29 Despite strong evidence of effectiveness, device use remains low in contemporary trials, especially those with a large proportion of patients enrolled in regions other than North America and Western Europe, where there is greater uptake of cardiac resynchronization therapy (CRT) and, in particular, implantable cardioverter defibrillators (ICDs).
21 Assuming that this variability is also representative of other groups, and further, that a relevant effect to be detected between ages (younger and older) amounts to 23 points on this scale, leading to an effect size of 0.75, then 70 90 patients should be enrolled per region (approximately 80 patients overall) with a precision of 95% (ie, 95% confidence interval [CI]).
Due to vague boundaries of the catchment areas of the hospitals in these other regions, enrolling patients at the ED would not provide us with valid information about case-load.
From a potential standpoint, the region has more than 30 four-year colleges and universities in the region, enrolling approximately 120,000 students, with options ranging from community and technical colleges to the esteemed Saint Louis University and the nationally recognized and prestigious Washington University in St . Louis
Subjects enrolled from all regions of the country, 26 cases were clinical encephalitis with laboratory-confirmed for JE IgM titer, while 103 controls had past illness free on encephalitis.
Our study populations were enrolled from defined regions, were of Caucasian ancestry and were less probably influenced by population stratification [ 34].
Families enroll from various regions when their babies are younger than 5 months of age, and they are invited to attend multiple research visits until their children reach 3 years of age or beyond.
To provide a representative view of Italian needs, such as in other epidemiological studies,,,, a large sample of patients with different MS severity levels was enrolled across Italian regions from several sources.
From 27/12/2010 - 13/05/2011, 252 cases could be potentially enrolled in the regions targeted by this study, representing 87.3% due to N. meningitidis of W serogroup and 11.5% of S. pneumoniae.
