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Bajantri et al. [ 22] recommend their use for defects up to 50 cm in size; however, we believe that we are very far from establishing a maximum flap size, which depends on the patient's body and leg size, skin laxity, flap volume, perforator enrolled, adequate donor site closure and many other factors.
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Once clinical trials begin, researchers frequently do not enroll adequate numbers of women or, when they do, fail to analyze or report data separately by sex.
Because the participation of women in HIV clinical trials varies greatly with geography and sociodemographic makeup, ongoing local assessment of recruitment and retention barriers is important for ensuring future success in enrolling adequate numbers of women in HIV clinical trials.
In this exploratory study, we also did not adjust α for multiple analyses, and future studies enrolling with adequate power and enrolling larger number of patients need to be conducted.
To enhance the likelihood of enrolling an adequate number of adult participants with more severe AKI, we have set an enrollment target of at least one third of AKI participants having ≥100% relative increase in serum creatinine.
With the failure of 2 VRE-BSI clinical trials to enroll an adequate number of subjects, and the low likelihood of having a "gold-standard" prospective randomized clinical trial, does a single well-designed observational study reporting on the largest published experience with VRE-BSI finally define the optimal therapy for VRE-BSI?
In clinical trials, sample sizes are planned ahead of time to ensure that the number of subjects to be enrolled will be adequate to address the question.
Most studies of the outcome of trichiasis surgery had few patients enrolled and lacked adequate power to compare differences between men and women (25 ).
It was also observed that only 7.5% of those without adequate knowledge enrolled.
Twenty-five consecutive patients were then enrolled; all presented an adequate ultrasonographic window.
Between February 2006 and February 2009, 102 severe sepsis subjects were enrolled, and 95 had adequate brachial artery reactivity measurements.
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