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Firstly participating centres were at liberty to decide which patients they would enrol; subjects were not, therefore, enrolled consecutively, thereby introducing a potential for selection bias.
41 43 For comparative trials to be of value, they must enrol subjects and use therapies that are similar to those used in routine clinical practice.
For the above practical reasons, it is common in practice that trials enrol subjects with different reactions to treatments into the same trial and aim to demonstrate its overall efficacy.
Similar(57)
We aimed to enrol 1000 subjects at each location.
Consequently, we need to enrol 60 subjects per group.
The objective was to enrol 1000 subjects; 765 have been recruited with 621of these having complete imaging baseline data.
This case-control design will enrol representative subjects from the community being this procedure an important technique to overcome Berkson bias.
The trial will enrol 350 subjects and is set up to assess whether this regimen can enhance the rate of spontaneous resolution of HCV infection.
The decision to prescribe a BoNT-A preparation was taken prior to, and independently from, the decision to enrol the subject in the study.
The protocol originally assumed that the study would enrol approximately 2600 subjects.
It was planned to enrol approximately 120 subjects into the study, assigned randomly and equally to each of the treatment groups.
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