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We estimate that about 30% of smokers approached will enrol, based on 45% recruitment rate in a "cessation induction" trial of incentives that used similar eligibility criteria, conducted in the US [ 14], and estimated 14% and 10% recruitment rates to two recent UK "aid to cessation" trials for pregnant women trying to quit smoking and not involving any financial incentives [ 31, 32].
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83 In both countries, the trials enrol pregnant women identified in community-based surveys who expect to deliver in the 6 months following enrolment based on date of last menstruation.
After enrolling an intervention site of this size, we will enrol a control site based on the same population range suitable for that latrine type: existing shared sanitation serving 15 20 people.
The decision whether to enrol a patients is based on the RDT result.
We will recruit the first 300 MSM/TGW in each group (with and without AGW) who agree to participate and meet eligibility criteria, and we expect to enrol 5 20% TGW based on current visitors at Epicentro (unpublished data).
Next, the expert panel performed a threshold identification exercise designed to assess the members' willingness to enrol 47 paper cases, based on having sufficient confidence that the individual has gout, into a Phase 3 randomised clinical trial of a new urate-lowering agent with unclear efficacy and safety.
The choice of 100 prior laparoscopic resections to enable surgeons to contribute to EnROL is both intuitive and based on data from studies examining the acquisition of surgical competence with this approach [ 36].
Recruitment of panel members with relevant experience or expertise underpins the validity of this study, and processes used to enrol panel members varied by sampling strategy based on the need to confirm relevant expertise prior to enrolment.
This was especially the case for children enroled at younger ages, but is based on only 29 embryonal CNS tumour cases, and the CIs are wide.
Based on the assumption that about one third of patients will not return to work (indicating chronification) and the assessment of about 30 covariates we will need to enrol about 700 patients.
These studies typically enrol cases with active TB and "fingerprint" their isolates based on distinct genomic polymorphisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com