Pathway analysis of the top associated polymorphisms and genes confirmed the enrichment of processes relevant to BD and white matter development, including axon guidance, ErbB-signalling neurotrophin signalling, phosphatidylinositol signalling, and cell adhesion.
Functional analysis also revealed enrichment of processes involved in innate immune response.
Both analyses showed an enrichment of processes related to protein modification and metabolism (among others).
Data from enrichment of processed 5'-ends was ambiguous with a very high proportion of 5'-ends present in both the primary and the processed transcript-enriched samples.
Each bar plot summarizes the genes that contribute the most to the enrichment of processes with the same node color as the plot border.
The former exhibited an enrichment of processes linked to cytoskeletal reorganisation, with the top five significant terms being leucocyte transendothelial migration, bacterial invasion of epithelial cells, regulation of actin cytoskeleton, focal adhesion and muscle contraction.
While there was no consistent enrichment of Gene Ontology Biological Processes or Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways based on dietary intake for HPV tumors, for HPV tumors there was a significant enrichment of processes involved in immune function based on vitamin B12 intake.
Gene ontology (GO) analysis of upregulated genes in Wk9 over Wk5.5 hPGCs also showed enrichment of biological process terms, such as "male meiosis" and "piRNA metabolic process".
We also analyzed the enrichment of biological process GO terms in our SUMO proteome when compared to the early Drosophila embryonic proteome (2 hr AEL embryo [39], [40]) (Table S6).
To analyze the enrichment of biological process in the consensus list of target genes, we used the pathway analysis tool DAVID [ 30, 31].
