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Specifically, our study power was enhanced by selecting a genetically enriched study population predisposed to breast cancer, by using a counter-matched design, and by developing a dose reconstruction method to reduce the error in estimating individual radiation exposure derived from imperfect and old medical records.
The "sponsor view" is motivated by the work of Beckman et al. (2011) who suggest to use Phase 2 data to decide whether performing an (adaptive) enriched study or not.
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Disability in the Modern World: History of a Social Movement is a landmark online collection that fills the gap, with a comprehensive and international set of resources to enrich study in a wide range of disciplines from media studies to philosophy.
Enriching study populations for subjects displaying certain biomarker levels may result in studies of greater efficacy, translating to reduced cost and duration.
Enriching study populations with rapidly progressing patients may offset some of this effect, but this necessitates the availability of prognostic markers that can accurately identify which patients are most likely to develop erosive damage and functional disability.
The simple unbiased analysis of intracellular localization presented in this work may considerably enrich studies on the local regulation and function of many mRNA species.
This was not a randomized study, and viral load testing could have enriched this study as a more accurate measure of disease burden.
That approach has greatly enriched the study of the better-remembered wars, but the doughboys still await such a history.
He enriched the study of French Renaissance literature with his interest in neo-Latin literature and the reception of ancient Latin and Greek literature in early modern Europe.
Although the name Rowland is no longer visible on the bricks and mortar of Homewood campus, his mark remains through contributions that have enriched the study of physics and benefited nonphysicists as well.
We thank you all the participants in the dissemination workshop for the valuable comments that enriched the study further.
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