As the broadcast unfolds on television, alongside it flash synchronised Web pages of enriching background information.
Phages displaying endoxylanases were strongly enriched from background phages displaying unrelated proteins.
This genomic region is, however, enriched above background noise and can be distinguished if signal intensities greater than 2 standard deviations, rather than our cut-off for dominant peaks of 4 standard deviations, from the mean signal intensity are examined.
No motifs were found to be significantly enriched over background (data not shown).
Sequencing data were first filtered to identify reads significantly (p<0.05) enriched over background signal using a Poisson-based test.
Apart from GRB2, SHP1 and SHP2, no other protein was comparably detected or enriched over background in subsequent MS analyses.
Twenty-five peaks were subjected to experimental validation through ChIP-PCR, of which 16 were identified as enriched over background by ChIP-PCR and thus called 'positive' (i.e., TP).
We found that in healthy subjects EZH2 and H3K27me3 were enriched above background at the promoters of ANT1, FRG1, and FRG2, even though they were at lower levels than those in NDE.
Fold enriched over background is defined as (m/n)/(M/N), where M genes out of total N genes are disease related, and within a given gene set with n genes, there are m genes that are disease related.
Direct targets were significantly enriched over background in AML1-binding sites with 2.6 AML1-binding sites/1 kb (±1.7; ±1 s.d.; P-value <0.001), whereas promoters of genes whose mRNAs and proteins were regulated indirectly upon TEL-AML1 expression were not (0.9±0.5 AML1-binding sites/1 kb; mean±1 s.d.; P-value=0.144).
Furthermore, both the average phenotype probabilities and the fold enriched over background (Methods) for the genes with high HT or T2D phenotype probabilities (> 95% specificity, see below) increase as the distance gets closer to the genomic locations of GWAS SNPs (Fig. 3C).
