We propose the design of self-adaptive software components based on logical discrete control approaches, in which the self-adaptive behavioural models enrich component controllers with a knowledge not only on events, configurations and past history, but also with possible future configurations.
Significantly enriched components defined in Gene Ontology (GO) were determined based on hypergeometric distribution analysis [ 38].
Both GD1a and GT1b are enriched components of membrane domains in neurons (Cantù et al., 2011; Sonnino et al., 2013).
The background and enriched components were modeled using G/C content and an interaction term between mapability and local background estimate.
This can be explained by the addition of a 3He-enrich component related to solar energetic particle events such as flare events.
The ASTI 3 data enriching component is responsible for linking the critiquing module to the EPR.
The data enriching component is also in charge of computing various medical abstractions, such as relative posologies (i.e. has the drug dose been increased or lowered in the new prescription?).
The ASTI 2 critiquing module is a rule-based system, with (a) a data-enriching component, which computes derived patient data from data available in the patient files, e.g. computing the Body Mass Index (BMI) from the height and the weight, (b) an inference engine, and (c) two knowledge bases implementing the French CPGs for hypertension [ 22] and type 2 diabetes [ 23].
Among the enriched molecular functions in both analyses were the "structural constituent of muscle" and "motor activity categories", while the "calcium channel regulator activity" was enriched in the LowCa list; finally, enriched cellular components included "sarcomer", "myofibril" and the troponin/myosin complexes.
Whereas there were no presence of significantly enriched cellular components, three molecular functions were found to be enriched at p < 0.05 level, including NADH dehydrogenase activity, oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor, and NADH dehydrogenase (quinone) activity.
Some gene sets are particularly highly specialized, such as cluster 38 (enriched in Maurer's clefts proteins) and cluster 19 (enriched in components of the Plasmodium translocon for exported proteins, PTEX).
