Sentence examples for enormous variability of the from inspiring English sources

The enormous variability of the mutations combined with the fact that more than 50%% of mutations occur in the cell before the cancer phenotype is established introduces a high noise to signal into genome and/or exon sequencing that confounds the interpretation of data [30, 31].

In fact, Polyzos and Devroey [ 1] emphasized enormous variability of the definitions of poor responder patients proposals from the literature (in 47 randomized trials, 41 different definitions).

Studies showed the changes of the V3 loop of gp120 lead to resistance, but mutations have also been reported in other regions of gp120 and gp41 due to the enormous variability of the env gene.

In psycholinguistic studies involving L2 speakers, however, a problem arises that is virtually absent in monolingual research namely, the enormous variability of the participants' proficiency levels and, in particular, of levels of vocabulary size, even within learner groups exposed to relatively homogeneous learning conditions.

Despite the enormous variability of influenza viruses, the induction of specific neutralizing antibodies through vaccination continues to be an effective intervention for seasonal influenza prevention, with the constant challenge of renewing the vaccine strain formulation every year in order to counteract the antigen drift, and the limitation of being ineffective in pandemic prevention [ 4, 5].

One of the greatest challenges facing the iPSC modeling field is the enormous variability of different iPSC lines and the neurons derived from them.

The enormous variability of mutations, combined with the fact that more than half of these occur even before the cancer phenotype is established, leads to an elevated " noise to signal" ratio in the exon sequencing data [ 26, 27].

The RAG1 and RAG2 proteins are essential subunits of the V(D J recombinase that is required for the generation of the enormous variability of antibodies and T-cell receptors in jawed vertebrates.

These latter unexpected results emphasize the enormous variability of tropical tropospheric ozone and hydroxyl concentrations, which determine the oxidizing efficiency of the troposphere.

In sharp contrast to the situation in chronic myeloid leukemia (CML) where one single cytogenetic abnormality, the translocation t(9 22)(q34;q11), is the genetic hallmark of the disease, there is an enormous variability of cytogenetic abnormalities in MDS hampering not only the prognostic classification but also the delineation of the molecular background of cytogenetic aberrations in MDS.

In addition, the high cost of errors, lack of training data, and enormous variability of input data all impede the applicability of MLAs to intrusion detection.