Clinically, there is also significant treatment failures, untoward side effects and enormous cost associated with oral anti-diabetic drugs generating an urgent need and desire for alternative treatments [ 8].
However, as the quotes show, these sources often propagated myths (infertility, birth defects) and exaggerated rare side effects (uncontrollable bleeding, enormous weight gain/loss).
Contrary to synthetic drugs, antimicrobials of plant origin are not associated with many side effects and have an enormous therapeutic potential to treat many infectious diseases [ 2].
Although the difficulties of clinical application are enormous, such as the bioavailability, dosage, and side effects, scientists are still trying to seek out the detailed mechanism and the suitable clinical administration of resveratrol.
In this regard, nutritional phytochemicals and plant derived constituents such as flavonoids, phytosterols, triterpenoids and essential oils hold enormous possibilities for development of a therapy with considerably fewer side effects for treatment and prevention of cancer [ 8].
These are the costly side effects — the dark side, if you will — of America's enormous technological progress over the last decade.
NPs as delivery carriers of anticancer drugs have enormous merits, including site-specific targeting [9], reducing doses, ensuring drug efficacy, minimizing side effects, protecting drugs against degradation, and enhancing drug stability [10, 11].
But enormous dosages of monetary medicine continue to be administered and, before long, we will need to deal with their side effects.
Enormous efforts have been devoted to classify and subgroup MB in order to improve prognosis and to reduce treatment-associated side effects.
Despite enormous advances in the treatment of RA, a significant number of patients either fail to respond to treatment or develop significant side effects.
