Recent advances in the development and discovery of pharmacological interventions within the ubiquitin proteasome system (UPS) have uncovered an enormous potential for possible novel treatments of neurodegenerative disease, cancer, immunological disorder and microbial infection.
Assuming that each parameter can be treated by using any of 10 possible interventions, the enormous potential number of cointerventions represents a formidable challenge in clinical trial design [ 2].
More recently, however, advances in sequencing technology have made the identification of sequences that make up these enormous genomes possible (Smith et al. 2005, 2009; Sun, Arriaza, et al. 2012; Sun, Shepard, et al. 2012; Zhu et al. 2012; Voss et al. 2013).
I believe that reports of possible enormous defaults are overstated.
When it comes to the backlash that so often accompanies feminist campaigning, having a group of fellow feminists to support you is obviously an enormous advantage, if possible.
An enormous opportunity made possible by the economic growth we've had for the last decade and by the Democratic leadership of Bill Clinton, Al Gore and the Democratic Congressional candidates who helped make it possible.... Our problems are well known.
China's enormous exports — made possible, in part, by voracious American consumers — have helped generate enough prosperity to ensure a reasonable degree of social stability, several China experts said.
Last week the committee released a letter from an Enron vice president, Sherron S. Watkins, that warned Mr. Lay last August about enormous losses and possible illegalities in several Enron partnerships.
Mr. Gabriel referred to a 1995 interview in Wired magazine in which Mr. Eno said: "An artist is now much more seen as a connector of things, a person who scans the enormous field of possible places for artistic attention, and says, 'What I am going to do is draw your attention to this sequence of things.' There is no longer such a thing as art history, but there are multiple art stories.
