Sentence examples for enormous mutation rate from inspiring English sources

It can be expected that ultra-hypermutated cancers, due to their enormous mutation rate, exhibit sufficient genomic flexibility to rapidly acquire resistance against most therapies and, in particular, targeted therapies.

Finally, it is worth commenting that the enormous population mutation rate (4Ne μ) reported for C. savignyi (Vinson et al. 2005; Small et al. 2007), which is the double of that of O. dio i ca, is somewhat puzzling.

Viruses present an enormous diversity due to their high mutation rate, short replication time, and high number of replicates.

Indeed, since the high mutation rate results in enormous tumor heterogeneity, most likely already at the beginning of a therapy, the mutations conferring resistance to the chosen drug will be present in a subset of tumor cells.

Significantly mutated genes (SMGs) were defined as the somatic mutations with higher mutated frequency than background mutation rate.

The P-criterion implies that an enormous sample size is required to identify a pathogenic variant of the average mutation rate.

Mutation rate: mutations per cell per generation.

Lynch, M. Evolution of the mutation rate.

(b) Region with increased maternal mutation rate on chromosome 9 (chr9: 0-10,000,000).

The mutation rate was set to 2 × 10−8.

Genomic factors that affect mutation rate in non-coding elements.