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However, regarding the complexity and enormous computational effort, this is practically impossible.
In explicit models, the single solvent molecules are modelled which leads to enormous computational effort as the number of particles in the simulation system increases exponentially.
Despite providing very accurate estimates, the low abstraction level adopted by current approaches demands an enormous computational effort, which restricts the applicability for large codes.
Damage identification of a large and complex bridge structure often requires an enormous computational effort to solve an ill-posed inverse problem with a large number of unknowns.
This means that, in each optimization step, a large finite element problem must be solved for each load case, leading to an enormous computational effort.
If we try to consider the explicit flexibility of receptor and ligand, the conformational space to be considered quickly becomes impractical [ 8, 9], as the process would require an enormous computational effort.
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After an enormous amount of computational effort, this produces a realistic, textured character.
Hence, due to the enormous difference in computational effort and time, clear preference can be given to the simpler sectional model.
The deterministic models require an enormous number of operating environment information and huge computational effort, while semi-empirical models obtained as their empirical modifications have a moderate complexity.
The computational effort required to manipulate such a large set of data becomes enormous.
This approach, however, requires high computational effort.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com