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"They accept the fact that their world is an enormous cell.
A single enormous cell, the amoeba was studied by Dr. Schliwa and colleagues to understand movement from one part of a cell to another, a process that was both easily visualized and carried out extremely rapidly in the big Reticulomyxa, which at its largest could house a billion or more nuclei as it constantly shuttled cell parts and whatnot across its titanic form.
The underlying mechanisms of coordination are likely to be particularly complex during neural development due to the enormous cell diversity in the brain.
The enormous cell surface area that requires constant maintenance is also an Achilles' heel for many neurons as it increases the need for energy, which, in turn, is dependent on mitochrondrial function.
If the white adipocytes arise exclusively from proliferation and differentiation of precursor cells, it would require an enormous cell turnover during the transition phase of the transformation, including extensive death of mature brown (or brite/beige) adipocytes.
With the microarrays becoming cheaper and next-generation sequencing platforms being rapidly developed, it is foreseeable that a large amount of parallel miRNA and mRNA expression datasets are attainable in the near future, and thus, our modeling strategy can be extended to enormous cell types, strains, tissues, and so on.
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In a separate line of research, Dr. John M. Allman, a neuroscientist at the California Institute of Technology, and his colleagues have delved below the level of brain structure to identify a special class of neuron -- spindle cells -- that are relatively enormous cells that collect information from one region of the brain and send it on to other regions.
Understanding the regulatory mechanisms that underlie the enormous cell-type diversity of the CNS is a significant challenge.
Cellular composition of TRF2 Δ/Δ -K5-Cre p53 −/− skin showed very few enormous cells, which presented giant nuclei and dense chromatin, a strong indication of the occurrence of massive endoreduplication (blue arrow heads in Fig. 4A).
All of these enormous cells have some device for escaping the consequences of their large size when they reproduce, either by cleaving only a small portion of their mass, as in reptilian or bird eggs, or by subdividing all or part of their large cell bodies to produce swarms of diminutive progeny, as in centimeter- and meter-scale marine unicellular organisms such as Acetabularia or Caulerpa.
Just two detainees, their paperwork complete, sit timidly in the corner of an enormous holding cell.
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