Given that the authors favor a cofilin gradient model, it is surprising that the Discussion fails to include a reference to work published from the Zheng lab in Nature Neuroscience (Gu J, et al., Nat Neurosci 13, 1208-1215, 2010) in which cofilin inhibition by LIMK1 was required for LTP-induced spine enlargement, a role proposed here for the LIMK1 in spines.
The Holy Spirit that "blows where it wills" has often been recognized as the impulse behind an enlargement of roles for women in the church.
However some research has also found that role enlargement must be undertaken cautiously because unabated expansion can eventually threaten professional identity, intensify workloads to the point of excess, and spark significant levels of demotivation and dissatisfaction.
Keynes gradually gained support for his ideas, the consequences of which included an enlargement in the role of government in modern economies.
Role enlargement is the horizontal accrual and diversification of employees' skills.
Beyond its potential to reduce service fragmentation, role enlargement can also have a positive impact on staff members themselves.
In industry, role enlargement aims to change the scope of jobs in an attempt to motivate workers [ 113, 114].
Nurses, for instance, have reported negative outcomes associated with role enlargement, primarily as a result of having to undertake more tasks.
Such role enlargement has been present in many recent initiatives in which the main focus has been on practitioners' acquisition of additional, basic patient-care skills.
In health care, role enlargement has been part of efforts to shift service delivery from a task-oriented approach towards integrated care carried out by workers who are able to meet patients' multiple and complex needs [ 117].
