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After an initial small enlargement, damage grows at a constant rate until the last stage is reached when damage grows with an increasing rate to final failure.
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Furthermore, TiO2 NPs have been shown to play a role in inducing epithelial fibroproliferative changes, stimulating goblet cell hyperplasia and in instigating emphysema-like (such as alveolar enlargement) damages in the lungs [2], [10], [12].
Nato's secretary general added that enlargement would damage relations with the Soviet Union.
Altogether, these findings suggest that STAT3 signaling is required for HEC-23-induced lysosomal enlargement and damage.
Importantly, knocking down STAT3 significantly suppressed HEC-23-induced lysosomal enlargement and damage (Fig. 5B, 5C and 5E).
In mammalian cells, ervachinines A D induced lysosomal enlargement and damage, leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death.
A chest X-ray or an echocardiogram may also be performed to look for signs of heart enlargement or damage to the heart.
Decreased KL expression was observed in the lung along with an alveolar enlargement and damage after 6 weeks of ozone exposure, suggesting that loss of airway KL expression may be linked to the elevated levels of inflammation and oxidative injury.
But after several weeks of steady enlargement, the damaged hearts began to contract poorly, resulting in heart failure.
MEPs warned that failure could damage enlargement.
After an initial small enlargement (stage 1), damage grows at a constant rate (stage 2) until the third stage is reached when there is further growth at an increasing rate to final failure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com