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Cells undergoing senescence-death are characterized by polyploidy (>4N DNA in mammalian cells) and enlarged sizes [4] [6].
Pink1 and park mutants displayed a heterogeneous population of mitochondria with the majority having significantly enlarged sizes and mild or severe disruption of their cristae structure, when compared to control mitochondria (Fig 2B, F, I-M).
All flies had similar, enlarged sizes relative to the starting populations, demonstrating that selection for large size had functionally equivalent genetic effects on size that were independent of aPO2.
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Indeed, both enlarged size and increased number of subcutaneous adipocytes could lead to accumulation of fat in non-adipose tissue, such as skeletal muscle, liver and heart.
As expected, HCM iPSC-derived CMs exhibited enlarged size, disorganized sarcomere structures and arrhythmic beatings.
The first signs of senescence, slow growth, enlarged size and flat morphology, were noted after 45 to 60 days.
Enlarged size of late endosomes and/or lysosomes, accompanied with increased levels of autophagy and lysosomal proteins, raised two possibilities.
Abdominal ultrasound showed enlarged size of right (145 mm) and left (180 mm) kidney with multiple simple renal cortical cysts with a maximum diameter of 3 cm.
Your skirt should gather slightly around the elastic because of the enlarged size.
This bioreactor culture facilitates cell proliferation and enlarges sizes of β-cell aggregates with enhanced responsibility to glucose level and incretin level [ 125].
These results support the hypothesis of Hirao et al. (2008) that the accD reading frame has displayed a tendency toward enlarging sizes in cupressophytes.
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