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The enlarged interaction interface of the inhibitors resulted in extension of small molecules binding toward the "lid" segment of MDM2 (residues 19 23)—a nascent element that interferes with p53 binding.
Longer proteins and repeat-rich proteins tend to have a higher connectedness within interaction networks, suggesting that they contribute to an enlarged interaction surface and constitute more flexible subunits[ 36].
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The weakened mesh, however, is further enlarged through interactions with importins to transport their complexes with NLS-tagged BSA.
The SC-PCF has a solid core with triangular lattice cladding structure, and one third of the cladding is removed intentionally to enable fast liquid infiltration and enlarge effective interaction area between liquid samples and the fiber core guided lightwave.
As a result, the originally narrow active site cleft could gradually be enlarged by the interaction forces between Png1p-ΔH1 and the substrate, thus allowing substrates to access the deep active site more easily.
In contrary, with swamping amount of electrolytes, synergistic interactions enlarged with the rise of EO groups, and AOS activity in mixed micelles was found depending on both EO length and bulk mole fraction (αA).
Analyzing at a finer level the two regions of the map, it became clear that there are five central nodes of interactions, enlarged in Figure 4b.
e, Enlarged view of the interaction between HSP101 Y488 and Y491 and the three-turn helix, shown with corresponding cryo-EM density (mesh).
ADAM: Enlarged prostate, enlarged prostate, enlarged prostate!
The analysis of protein-protein interactions indicated that HPV16 enlarged its scope of influence by interacting with human proteins as much as possible, and these interactions alter a broad array of cell cycle progression.
In addition, many isolation and purification techniques and quantitative strategies in conjunction with MS can significantly improve the sensitivity of mass spectrometry for detecting low-abundant proteins, replenishing the stock of virus proteome and enlarging the protein protein interaction maps.
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