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The result is a substantially enlarged brain.
Nishimura et al. reported that adiponectin-deficient mice had enlarged brain infarctions and increased neurological deficits after ischemia/reperfusion compared with wild-type mice, whereas adiponectin treatment increased the protective effects in wild-type mice.
A causal role of Bax was not pursued in the present study because Bax −/− mice displayed grossly enlarged brain volume and brain weight when compared with wt littermates (Supplementary Figures 1c and d).
This overall phenotype is very similar to that of Pten knockout in bone marrow stem cells and central neural stem cells as over-expansion of short-term hemeatopoietic stem cell pool and enlarged brain [ 6– 8].
In that case, the substitution of 8701A/10398A for 8701G/10398G preceded brain enlargement in H. habilis [59] and led to better energetic balance for an enlarged brain of higher complexity.
An enlarged brain artery indicates that too little nutrition is crossing the placenta.
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The Stanford researchers will lead a project in which induced pluripotent stem cells, or iPS cells, are produced from children with autism who also have enlarged brains, or megalencephaly.
In addition, Ate1-deficient mice have enlarged brains, an enhanced startle response, and are strikingly hyperkinetic.
In addition, Ate1-deficient mice have enlarged brains, an enhanced startle response, are strikingly hyperkinetic, and are prone to seizures and kyphosis.
Transgenic mice overexpressing β-catenin in the CNS developed enlarged brains because a greater number of their periventricular neural progenitor cells re-entered the cell cycle [ 13].
Conditional disruption of Tsc1 in astrocytes, using a GFAP-Cre driver, produced mice that demonstrated enlarged brains, an astrocytosis and mTORC1 activation (36).
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