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Indeed, it has been said, there were only two people who thought the Enigma could be broken: Frank Birch, the head of Bletchley's naval-intelligence division, because it had to be broken; and Alan Turing, because it was an interesting problem.
In principle, ENIGMA could be used to study rare variants as well, but a range of complementary approaches are always necessary.
The concept of the African enigma has been challenged since it has been suggested that the enigma could be explained due to lack of infrastructure and access to hospitals and care in African countries resulting in incomplete reporting of gastric cancer.
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His Elgar, as exemplified in the Enigma Variations, could be arrestingly exuberant in the extrovert movements, but imparted a wonderful lyrical sweep in the more intimate ones.
Turing refused to speak to him afterwards - until the new boy used his statistical expertise to demonstrate how an essential trial-and-error method of attacking Enigma traffic could be accelerated.
The critic Brooks Atkinson, reviewing "Godot" in the Times, in 1956, called the play "a mystery wrapped in an enigma," and the same could be said of Beckett.
More complex than the famous Enigma code, the Lorenz cipher could be broken only thanks to the mathematician Bill Tutte, who deduced the architecture of a Lorenz machine without ever having seen one.
This limitation is not specific to ENIGMA, and its consortium structure could be expanded geographically to assess ethnic differences in factors associated with disease and their relationship to brain structure.
On the basis of these contradictory observations, it remains an enigma how an efficient hydrodynamic force could be created and how it controls over the supramolecular chirality during the self-assembly process.
While paucity or absence of MS in some suprahyoid muscles still remains an enigma, few speculations on this condition could be purposed.
Not being able to perform interaction analyses (e.g., disease by SNP) is also a limitation, although this could be overcome as ENIGMA's disease related working groups expand.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com