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Given the role of FliC in these biological implications, this phenotype may be another component of ATR, enhancing the virulence of the pathogen in vivo.
The findings of the present study indicate that acid induced FliC might be one of the factors enhancing the virulence of serovar Typhi under the host acidic conditions and may prove to be helpful in designing the prophylactic measures.
Interestingly, the relative abundance of the transcripts with unknown mechanisms in PSR subgroup (26.79 %) was higher than those in PDR subgroup (19.12%), suggesting possible novel functions enhancing the virulence of the parasite.
The genomic island contained a terminal transposase (the only transposase gene found throughout the genome), which may facilitate HGT of the genomic island containing tetracycline resistance genes enhancing the virulence of C. suis R19 (Donati et al. 2011).
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EPS productivity is known to enhance the virulence properties of otherwise innocuous or relatively low virulent bacteria [ 7, 8, 16, 17].
Previous studies demonstrated that pRST98 could enhance the virulence of its host bacteria.
Others have reported that Escherichia coli lipopolysaccharide (LPS) acts as a copathogen to enhance the virulence of parenteral C. albicans.
O44 Cytomegalovirus reactivation enhances the virulence of a Staphylococcus aureus pneumonia in a mouse model.
According to another member of the research team, Dr Hendrik Poinar, a combination of factors enhanced the virulence of the medieval outbreak.
Co-aggregation of different microbial species can enhance the virulence characteristics of certain bacteria, as well increasing their tolerance to antimicrobials [15].
In contrast, specific depletion of neutrophils via mAb 1A8 treatment did not enhance the virulence of BJx109 for B6 mice, suggesting that alternative immune defenses are sufficient to contain and clear infection.
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