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Enhancing the affinity of scaffolds for endothelial cell (EC) is a crucial procedure for promoting angiogenesis in tissue engineering.
In addition, substitution of the residues Pro211 and Ala212 or residue Glu221 which localized in the vicinity of a Ca2+ binding site of the enzyme by the corresponding residues in subtilisin S41 remarkably reduced the half-life of the enzyme at 70 °C, suggesting that the three residues contributed to the thermostability of the enzyme, probably by enhancing the affinity of enzyme to Ca2+.
FSS stimulation of osteoblasts also improved the cell adhesion by enhancing the affinity of intracellular integrins to extracellular matrix ligands as well as to biomaterial surfaces [20, 21].
To further illustrate the effect of nitrogen doping in enhancing the affinity of pore wall, the isosteric heats of adsorption are calculated from the CO2 adsorption isotherms at 25 and 75 °C by using the Clausius-Clapeyron equation [37 41].
Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy.
eIF4G contributes to message selection by enhancing the affinity of these two factors for their substrates [2], [3], [4].
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These interactions significantly enhance the affinity of this MOF for unsaturated hydrocarbons.
Multiple ligand presentation is a powerful strategy to enhance the affinity of a probe for its corresponding target.
These two substitutions enhanced the affinity of p53 for specific DNA yet, counterintuitively, decreased the residency time of p53 on DNA.
Introducing an appropriate substituent into position-9 of β-carboline nucleus enhanced the affinity of the drug to DNA resulting in remarkable Topo I inhibition effects.
More dramatically, these same agents enhanced the affinity of the receptor by ten-fold, without affecting the specificity of the receptor.
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