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The genomic overrepresentation of these DNA uptake enhancing sequences (DUES) causes preferential uptake of conspecific DNA, but the function(s) behind this overrepresentation and its evolution are still a matter for discovery.
The reason of prediction inaccuracy for non-canonical PTS1 proteins is that the proteins containing canonical PTS1 tripeptides dominate the dataset, most of which lack upstream enhancing sequences for targeting [ 30, 39].
Here I suggest the unifying and more accurately descriptive name of DNA Uptake Enhancing Sequences (DUES) to highlight that both sequences are variants of the same genetic element which enhance the uptake of DNA rather than cause it.
Several promoter enhancing sequences (TATA and CAAT boxes) were identified in the region immediately upstream of the start codon of the 3CAR and CYP720B4 genes.
Additional research needs to be carried out to identify other factors (e.g., trans-acting factors, other PON1 polymorphisms including intronic and exonic splice enhancing sequences) that influence PON1 expression.
Similar(54)
Moreover, the 3'UTR of β-mRNA acts as a translation enhancing sequence [24], [33] that displays IRES-like activity in dicistronics constructs [32].
Additionally, there is a putative human intronic splicing enhancing sequence, GGGGAUU (nucleotides 171 177), within this structure.
While enhancing sequence coverage, the promiscuous sequence specificity of pepsin can also reduce peptide ion abundance in regions such as Leu Pro, where multiple overlapping fragments are generated.
The suitability of ECD as a means of enhancing sequence coverage and spatial resolution that can be achieved in HDX MS studies of disulfide-rich proteins was evaluated in this work using the 80 kDa glycoprotein human serum transferrin (Tf) as a model system.
Where there is suspicion of malignancy, dynamic contrast enhanced sequences are included.
Thus, early stages are not easily detectable on contrast enhanced sequences, due to lack of these features.
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