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Cabazitaxel treatment also leads to downregulation of the microtubule-depolymerizing mitotic kinesins, MCAK, and HSET, preventing their ability to depolymerize microtubules and thus enhancing sensitivity to taxane treatment.
That is, it cannot otherwise be predicted whether the autophagy induced by radiation or chemotherapy is associated with resistance and the circumstances under which autophagy inhibition might be a useful strategy for enhancing sensitivity to therapy.
The development of an efficient therapeutic approach would therefore require the identification of distinctive molecular pathways active in CSCs and the identification of agents that can either block CSC proliferation or induce CSC differentiation, thus enhancing sensitivity to chemotherapeutic drugs.
In summary, the results suggest that a multiple negative feedback loop structure confers desirable properties through enhancing sensitivity to both qualitative and quantitative changes of the photo-profiles and their robustness to noisy external fluctuations.
Trichostatin A, a histone deacetylase (HDAC) inhibitor, has been used in cancer research; it offers a novel approach to treating chemoresistant tumours by enhancing sensitivity to DNA damaging agents [29].
Note that for this detection geometry, there are no specular reflection effects, thus enhancing sensitivity to bulk sample polarization properties.
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"As a result of repeated presentation, the subjects developed enhanced sensitivity to the dots," he said.
COX enzymes are responsible for the conversion of arachidonic acid (a fatty acid) to prostaglandins, which enhance sensitivity to pain.
Using state feedback, closed-loop modal frequencies are placed at locations in the complex plane that enhance sensitivity to particular types of damage.
Average RGD spacing similar to that found in fibronectin leads to lipid raft accumulation at FAs, enhances sensitivity to VEGF stimulation, and controls migration in endothelial cells.
Prior research in rodents and humans suggests that odorant exposure may enhance sensitivity to that odorant; however, other research has suggested that exposure may have the opposite effect.
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