Through these actions, the drug enhances the availability of Ach released in a synaptic manner, thereby enhancing reflex-controlled motility.
Injurious stimuli augment the protective function of reflexes by enhancing (sensitizing) reflexes that protect the injured site and inhibiting those reflexes that might exacerbate the insult.
In the current study, the reduction in flexion reflex excitability following aspiration alone is a novel finding, suggesting that joint effusion may enhance flexion reflex excitability as well as increasing the excitability of other spinal reflex inhibitory pathways such as group I non-reciprocal (Ib) inhibition [ 4].
Evidence from animal studies suggests enhanced flexion reflex excitability may contribute to this weakness.
It has also been shown that inhaled prostaglandin E2 (PGE2), which acts as a bronchodilator, enhances cough reflex sensitivity [ 19, 20].
It has been also shown that inhaled prostaglandin E2 (PGE2), which acts as a bronchodilator, enhances cough reflex sensitivity [ 20, 21].
In our experiments, a higher level of CF synchrony after a strong periocular airpuff might serve to enhance the reflex response by generating a faster or longer duration eyeblink movement (Evinger et al., 1991).
Bradykinin is also implicated in sensitizing the cough reflex, enhancing cough response to citric acid [ 78].
We hypothesized that GRP administration might enhance penile reflexes in SPS-exposed males.
The bronchoconstrictor effect of acetylcholine is mediated mainly through M3-muscarinic receptors on airway smooth muscle cells, whereas M1-receptors enhance cholinergic reflexes.
Namely, that activation of TRPV1 receptors by capsaicin causes the release of substance P and the subsequent stimulation of rapidly adapting receptors, which may enhance cough reflexes.
