Sentence examples for enhancing potency from inspiring English sources

To achieve this goal, the αB-crystallin peptide was re-engineered into a protein polymer nanoparticle/macromolecule with the purpose of increasing the hydrodynamic radius/molecular weight and enhancing potency via multivalency or an extended retention time.

The two structural differences between compound 35 and trimethoprim show that the propargyl linkage and the substitution at C6 of the pyrimidine ring are critical to the formation of contacts with Thr 56, Ser 59, Ile 60, Leu 22, Phe 31 and Phe 34 and hence, to enhancing potency.

Additionally, the C-terminal repeats bind Ca2+ thereby enhancing potency of TcdA [8].

We also examined various N-arylmethyl substituents and found that a variety of aryl groups were effective in enhancing potency.

Solution to the problem is in enhancing potency of new drugs to shorten course of treatment, ensure patient's compliance, and achieve parasitological cure.

The substitution pattern favors meta- and para- mono-substitution, with 3,4-disubstitution (compounds 11) and 3,5-disubstitution (compound 13) modestly enhancing potency as well.

Bi-functional design may further enhance potency and safety of RNAi-based therapeutics.

Based on these results, a series of carbamates was designed that display enhanced potency.

Six compounds showed EC50 values below 35 nM, and several derivatives also exhibited significantly enhanced potency and high selectivity at the CB2 receptor over the CB1 receptor.

Thrombin inhibitors incorporating o-aminoalkylbenzylamides in the P1 position were designed, synthesized and found to have enhanced potency and selectivity in several different structural classes.

The systematic SARs revealed that the side chain of 2-methoxyethoxy has little impact on the activity and can be replaced by other functionalized groups, providing new MI-2 analogues with retained or enhanced potency.