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The robustness and safety of liver-directed gene therapy can be substantially improved by enhancing expression of the therapeutic transgene in the liver.
The co-delivered molecules (Sr ion and Phenamil drug) have profound effects on the differentiation and maturation of cells, i.e., significantly enhancing expression of osteo/odontogenic genes, alkaline phosphatase activity, and mineralization of cells.
Elevated PTGS2 expression and PGE2 biosynthesis and signalling has been shown to promote tumorigenesis by enhancing expression of angiogenic factors such as VEGF and increasing angiogenesis [27], [39].
Next, we addressed if ClpX controls Rot expression by enhancing expression of RNAIII that is an inhibitor of Rot translation [17].
Accumulating evidence suggest that heparanase functions as a pro-coagulation mediator, enhancing expression of tissue factor and generation of factor Xa, two critical components in blood coagulation [40] [42] thus providing another mode by which heparanase affects the vasculature.
We found that p55 TNFR expression promotes atherosclerosis, among other mechanisms, by enhancing expression of endothelial adhesion molecules, while it seems to have no major role in the development of AngII-induced AAA.
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Insulin promotes glycogen synthesis through enhancing expressions of phospho-GSK3 β (Ser9) and phospho-GS (Ser641).
The resulting strain, WYZ-L, has enhanced expression of the sucrose operon (cscA and cscKB).
We have additionally identified putative regulatory elements that may enhance expression of transgenic silks.
A murine genomic sequence equivalent to −10 has been shown to enhance expression of murine SCL in erythroid cells [33].
The mechanism by which motility agar enhances expression of chromosomal fusions (but not plasmid-based fusions) is not known.
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