Lipases/acyltransferases are a special group of lipases with highly enhanced affinity for other nucleophiles than water compared to classical lipases.
Introduction of Glu217 into trypsin variants containing the SSFI sequence exhibited enhanced affinity for the factor Xa ligands (2) and (3).
We provide evidence that the dominant contribution to improved PR-104A activity was enhanced affinity for the prodrug over-competing intracellular substrates.
Second, it is possible E.coli protein(s) exist that contain binding surfaces(s) analogous to binding surface(s) on TNF-α and enhancing TNF-α binding site affinity also enhances affinity for analogous sites on E.coli protein(s).
Both IC50 and δE2 values show C2 to have a significantly enhanced affinity for PLA2 as compared with C6, even though both are iso-lipophilic (Tables 1 and 2).
Does CBC have enhanced affinity for certain transcripts?
However, the TDO5 micelle conjugate displayed high affinity and selectivity for its target Ramos cells, as a result of densely packed aptamers that could enhance affinity for the target.
Because hydrogen bonds with the guanine moiety enhance affinity for cGMP in other CNB domains, we directly studied the hydrogen bonding interactions between PKG and cGMP.
Phosphorylated eIF2α exhibits enhanced affinity for the GTP-GDP exchange factor (GEF) eIF2B, competitively inhibiting the rate of nucleotide exchange, which in turn results in a reduced rate of TC formation (Dever et al., 1993; Hinnebusch, 2005).
An iterative cycle of library synthesis and screening enabled the discovery of two modified Zn-BDPA structures, 11k and 11o, that have enhanced affinity for bilayer membranes that contain the cell death membrane biomarker PS.
A strong epistatic effect (G3xT4) is also present, which further enhances affinity for the GT combination by 0.8 kcal/mole beyond that expected from the main effects of these two nucleotides.
